News & Events
The Drugs Technical Advisory Board has examined the issue of suspension of manufacture and sale of Pioglitazone on 19th July 2013 & has recommended that the Suspension of the drug should be revoked and allowed to be marketed subject to certain conditions the manufacturers shall mention on their package insert and promotional literature of the drug. Based on DTAB report Ministry of health & family welfare & Central Government revokes the notification G.S.R.379(E) dated 18th June 2013.
A new study presented at EULAR 2013,the Annual Congress of the European League Against Rheumatism shows that one in eight patients at risk of developing a serious adverse drug event (ADE) is taking over the counter (OTC) non-steroidal anti-inflammatory drugs (NSAIDs), often to treat a musculoskeletal complaint Possible serious ADEs include gastrointestinal bleeding, peptic ulceration, high blood pressureand worsening heart failure.
Researchers reported at the American Heart Association's 50th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, that the increase in sugar consumption has led to more diabetes and heart disease over the past decade.
People taking statin drugs to lower their cholesterol may slightly increase their risk for muscle and joint diseases as well as strains and sprains, a new study suggests.The results were published online June 3 in the journal JAMA Internal Medicine.

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Metoprolol Succinate(extended release) 50mg & Amplodipine Besilate 5mg Tablets
Treatment of hypertension, Angina pectoris, Cardiac arrhythmias, Adjunct in hyperthyroidism,  Prophylaxis of migraine, Stable symptomatic heart failure, Emergency treatment of cardiac arrhythmias, Prophylaxis or control of arrhythmias on induction of ana esthesia, Adjunct in the early management of acute myocardial infarction
AdultInitial: 50-100 mg/day in single or divided doses; increase slowly according to response. Maintenance: 100-200 mg/day. Extended-release 25-100 mg once daily. 
Angina pectoris
Adult50-100 mg 2-3 times/day
Cardiac arrhythmias
Adult50 mg 2-3 times/day up to 300 mg/day in divided doses if needed
Adjunct in hyperthyroidism
Adult50 mg 4 times daily.
Prophylaxis of migraine:
Adult100-200 mg daily in divided doses.
Stable symptomatic heart failure:
Adult: As succinate: Extended release Initial: 12.5-25 mg of equiv metoprolol tartrate dose. Increase slowly as needed. Max: 20 mg once daily. IV 
Emergency treatment of cardiac arrhythmias
Adult: Initial: ≤5 mg at a rate of 1-2 mg/min; repeat at 5-min intervals if needed up to a total of 10-15 mg. Maintenance via oral therapy: ≤50 mg 3 times/day 4-6 hr after IV regimen. 
Prophylaxis or control of arrhythmias on induction of anaesthesia
Adult: 2-4 mg as slow inj; repeat as needed. Max total: 10 mg
Adjunct in the early management of acute myocardial infarction
Adult:Administer w/in 12 hr of the onset of chest pain, 5 mg at 2-min intervals to a total of 15 mg, if tolerated. After 15 mins, initiate oral therapy at 50 mg 6 hrly for 2 days for patients who received the full IV dose. Subsequent maintenance: 100 mg PO twice daily.
2nd or 3rd degree AV block; sick sinus syndrome; decompensated heart failure; clinically relevant sinus bradycardia. Severe peripheral arterial circulatory disorders. Cardiogenic shock. Asthma. Phaeochromocytoma (without α-blockade), systolic BP <100 mmHg. Metabolic acidosis. Pregnancy (2nd and 3rd trimesters).
Compensated heart failure, bronchospastic disease, hepatic impairment, AV conduction disorders, bradycardia, peripheral arterial circulatory disorders. An α-blocker should be given concurrently in patients with phaeochromocytoma. May mask signs of acute hypoglycaemia. May mask symptoms of hyperthyroidism. Caution when used in patients with history of cardiac failure or those with minimal cardiac reserve. Avoid using anaesthetic agents that may depress the myocardium. May impair ability to drive or operate machinery. Myasthenia gravis; history of psychiatric disorder. Lactation. Avoid abrupt drug withdrawal.
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